Improvement of the approach to definition of patient release criteria after radionuclide therapy

Current patient release criteria established in NRB-99/2009 relate to four radionuclides used Russia that period of the document preparation. These were calculated only considering radionuclide decay. Thus, these give conservative assessments which require stay dedicated protected room (“hot” room) radiotherapy department for several days and do not allow therapy be given outpatient hospital certainly reduces availability this type treatment. Consideration biological excretion radiopharmaceutical will able make after significantly softer. Recently, new promising radiopharmaceuticals have appeared, introduction into medical practice is obstructed by lack criteria. study devoted justification improvement approach definition with applied radiopharmaceutical. As examples, calculations performed 177 Lu-PSMA, Lu-DOTA-T A TE, 131 I-mIBG и Na I. The dosimetric model calculation based on was current NRB-99/2009. Additionally, radiopharmaceutical, assessed according published data, considered. Two phases evaluated considered (fast slow fractions). main contribution decrease patient’s body during first hours injection made fast-eliminated fraction. During 4-6 administration about 50% eliminated via urine. slow-elimination fractions characterize activity release. following effective half-lives used: Lu-PSM – 60 hours, TE 100 45 I 7.5 days. demonstrate when planning a course administrations allowed at dose rate 20 μSv/h from distance 1 m; case 12 μSv/h. Considering fraction administration, it can assumed more patients normal renal function undergo hospital. Some may held “hot” rooms 1-2 until acceptable levels. consideration makes possible soften criterion times 10%. It earlier without reduce radiation safety people around increase capacity department.